78 research outputs found
Individual fatty acids and cardiovascular risk factors
This thesis focuses on the relationship of individual fatty acids in blood phospholipids with
blood pressure, serum cholesterol, triglycerides and apolipoproteins. A clinical trial and a
observational study address the following questions:
1. What are the effects of dietary supplementation with high doses (4 grams daily) of highly
purified EPA and DHA on serum lipids (triglycerides, total, LDL and HDL cholesterol,
apolipoprotein A and B), serum phospholipid fatty acid concentrations, blood pressure,
heart rate and left ventricular performance in middle aged healthy men?
2. What is the cross-sectional relationship of plasma phospholipid fatty acids concentrations
with blood pressure, serum triglycerides and total cholesterol among 40-42 year old men who participated in a population study
Using mobile sensors to expand recording of physical activity and increase motivation for prolonged data sharing in a population-based study
Source at http://www.ep.liu.se/ecp/article.asp?issue=145&article=005.Regularly conducted population cohort studies contribute important new knowledge to medical research. A high participation rate is required in these types of studies in order to claim representativeness and validity of study results. Participation rates are declining worldwide, and re-searchers are challenged to develop new data collection strategies and tools to motivate people to participate. The last years of advances in sensor and mobile technology, and the widespread use of activity trackers and smart watches, have made it possible to privately collect physical activity data, in a cheap, easy and prolonged way. The unstructured way of collecting this data can have other applications than just showing users their activity trends. In this paper, we describe our plans for how to use these pervasive sensors as new tools for collecting data on physical activity, in a way that can motivate participants to share more information, for a longer time period and with a renewed motivation to participate in a population study
Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials
Extracts of Chinese red yeast rice (RYR, a traditional dietary seasoning of Monascus purpureus) contains several active ingredients including lovastatin, and several trials of its possible lipid-lowering effects have been conducted. This meta-analysis assesses the effectiveness and safety of RYR preparations on lipid modification in primary hyperlipidemia. We included randomized controlled trials testing RYR preparation, compared with placebo, no treatment, statins, or other active lipid-lowering agents in people with hyperlipidemia through searching PubMed, CBMdisk, TCMLARS, the Cochrane Library, and AMED up to December 2004. Ninety-three randomized trials (9625 participants) were included and three RYR preparations (Cholestin, Xuezhikang and Zhibituo) were tested. The methodological quality of trial reports was generally low in terms of generation of the allocation sequence, allocation concealment, blinding, and intention-to-treat. The combined results showed significant reduction of serum total cholesterol levels (weighted mean difference -0.91 mmol/L, 95% confidence interval -1.12 to -0.71), triglycerides levels (-0.41 mmol/L, -0.6 to -0.22), and LDL-cholesterol levels (-0.73 mmol/L, -1.02 to -0.043), and increase of HDL-cholesterol levels (0.15 mmol/L, 0.09 to 0.22) by RYR treatment compared with placebo. The lipid modification effects appeared to be similar to pravastatin, simvastatin, lovastatin, atorvastatin, or fluvastatin. Compared with non-statin lipid lowering agents, RYR preparations appeared superior to nicotinate and fish oils, but equal to or less effective than fenofibrate and gemfibrozil. No significant difference in lipid profile was found between Xuezhikang and Zhibituo. RYR preparations were associated with non-serious adverse effects such as dizziness and gastrointestinal discomfort. Current evidence shows short-term beneficial effects of RYR preparations on lipid modification. More rigorous trials are needed, and long-term effects and safety should be investigated if RYR preparations are to be recommended as one of the alternative treatments for primary hyperlipidemia
Polar Vantage and Oura Physical Activity and Sleep Trackers: Validation and Comparison Study
Background: Consumer-based activity trackers are increasingly used in research, as they have the potential to promote increased
physical activity and can be used for estimating physical activity among participants. However, the accuracy of newer
consumer-based devices is mostly unknown, and validation studies are needed.
Objective: The objective of this study was to compare the Polar Vantage watch (Polar Electro Oy) and Oura ring (generation
2; Ĺura Health Oy) activity trackers to research-based instruments for measuring physical activity, total energy expenditure,
resting heart rate, and sleep duration in free-living adults.
Methods: A total of 21 participants wore 2 consumer-based activity trackers (Polar watch and Oura ring), an ActiGraph
accelerometer (ActiGraph LLC), and an Actiheart accelerometer and heart rate monitor (CamNtech Ltd) and completed a sleep
diary for up to 7 days. We assessed Polar watch and Oura ring validity and comparability for measuring physical activity, total
energy expenditure, resting heart rate (Oura), and sleep duration. We analyzed repeated measures correlations, Bland-Altman
plots, and mean absolute percentage errors.
Results: The Polar watch and Oura ring values strongly correlated (P<.001) with the ActiGraph values for steps (Polar: r=0.75,
95% CI 0.54-0.92; Oura: r=0.77, 95% CI 0.62-0.87), moderate-to-vigorous physical activity (Polar: r=0.76, 95% CI 0.62-0.88;
Oura: r=0.70, 95% CI 0.49-0.82), and total energy expenditure (Polar: r=0.69, 95% CI 0.48-0.88; Oura: r=0.70, 95% CI 0.51-0.83)
and strongly or very strongly correlated (P<.001) with the sleep diaryâderived sleep durations (Polar: r=0.74, 95% CI 0.56-0.88;
Oura: r=0.82, 95% CI 0.68-0.91). Oura ringâderived resting heart rates had a very strong correlation (P<.001) with the
Actiheart-derived resting heart rates (r=0.9, 95% CI 0.85-0.96). However, the mean absolute percentage error was high for all
variables except Oura ringâderived sleep duration (10%) and resting heart rate (3%), which the Oura ring underreported on
average by 1 beat per minute.
Conclusions: The Oura ring can potentially be used as an alternative to the Actiheart to measure resting heart rate. As for sleep
duration, the Polar watch and Oura ring can potentially be used as replacements for a manual sleep diary, depending on the
acceptable error. Neither the Polar watch nor the Oura ring can replace the ActiGraph when it comes to measuring steps,
moderate-to-vigorous physical activity, and total energy expenditure, but they may be used as additional sources of physical
activity measures in some settings. On average, the Polar Vantage watch reported higher outputs compared to those reported by
the Oura ring for steps, moderate-to-vigorous physical activity, and total energy expenditure
Measuring Physical Activity Using Triaxial Wrist Worn Polar Activity Trackers: A Systematic Review
International Journal of Exercise Science 13(4): 438-454, 2020. Collecting objective physical activity data from research participants are increasingly done using consumer-based activity trackers. Several validation studies of Polar devices are conducted to date, but no systematic review of the current level of accuracy for these devices exist. The aim of this study is therefore to investigate the accuracy of current wrist-worn Polar devices that equips a triaxial accelerometer to measure physical activity. We conducted a systematic review by searching six databases for validation studies on modern Polar activity trackers. Studies were grouped and examined by tested outcome, i.e. energy expenditure, physical activity intensity, and steps. We summarized and reported relevant metrics from each study. The initial search resulted in 157 studies, out of which fourteen studies were included in the final review. Energy expenditure was reviewed in seven studies, physical activity intensity was reviewed in four studies, and steps was reviewed in 11 studies. There is a large difference in study protocols with conflicting results between the identified studies. However, for energy expenditure there is some indication that Polar devices perform better in free-living, compared to lab-based studies. In addition, step counting seems to have less average error compared to energy expenditure and physical activity intensity. There is large heterogeneity between the identified studies, both in terms of study protocols and results, and the accuracy of Polar devices remains unclear. More studies are needed for more recently developed devices, and future studies should take care to follow guidelines for assessment of wearable sensors designed for physical activity monitoring
Changes in adiposity, physical activity, cardiometabolic risk factors, diet, physical capacity and well-being in inactive women and men aged 57-74 years with obesity and cardiovascular risk â A 6-month complex lifestyle intervention with 6-month follow-up
A key challenge in lifestyle interventions is long-term maintenance of favorable lifestyle changes. Middle-aged and older adults are important target groups. The purpose of this analysis was to investigate changes in adiposity, physical activity, cardiometabolic risk factors, diet, physical capacity, and well-being, in inactive middle-aged and older women and men with obesity and elevated cardiovascular disease risk, participating in an interdisciplinary single-arm complex lifestyle intervention pilot study. Participants were recruited from the population-based Tromsø Study 2015â2016 with inclusion criteria age 55â74 years, body mass index (BMI) âĽ30kg/m2, sedentary lifestyle, no prior myocardial infarction and elevated cardiovascular risk. Participants (11 men and 5 women aged 57â74 years) underwent a 6-month intervention of two 1-hour group-sessions per week with instructor-led gradually intensified exercise (endurance and strength), one individual and three 2-hour group counselling sessions with nutritionist (Nordic Nutrition Recommendations) and psychologist (Implementation intention strategies). We investigated changes in adiposity (weight, BMI, body composition, waist circumference), physical activity (self-reported and via physical activity trackers), cardiometabolic risk factors (blood pressure, HbA1c, blood lipids), diet (intake of energy, nutrients, foods), physical capacity (aerobic capacity, muscle strength), and psychological well-being, measured at baseline and end-of-intervention, using mean-comparison paired t-tests. Further, we investigated self-reported healthy lifestyle maintenance six months after end-of-intervention, and monthly changes in daily step count, moderate-to-vigorous physical activity (MVPA) and total energy expenditure. From baseline to end-of-intervention, there was a mean decrease in weight, BMI, fat mass, waist circumference, intake of total- and saturated fat, and increase in lean mass, lateral pulldown and leg press. We detected no changes in mean levels of physical activity, cardiometabolic risk factors or well-being. Six months after end-of-intervention, 25% responded healthy lifestyle achievement and maintenance, while objectively measured physical activity remained unchanged. The results are useful for development of a protocol for a full-scale trial
Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study
Aims/Background: Serial blood pressure surveys in cohort studies can inform public health policies to control blood pressure for prevention of cardiovascular diseases.
Methods: Mean levels of systolic blood pressure (SBP) were collected in six sequential surveys, involving 38,825 individuals aged 30â79 years (51% female), between 1979 and 2015 in the Tromsø Study in Norway. Mean levels of SBP, prevalence of hypertension and use of blood pressure-lowering treatment were estimated by age, sex and calendar year of survey.
Results: Age-specific mean levels of SBP in each decade of age increased by 20â25 mmHg in men and 30â35 mmHg in women and the prevalence of hypertension increased from 25% to 75% among adults aged 30â79 years. Among successive cohorts of adults aged 40â49 years at the time of the six surveys between 1979 and 2015, the mean levels of SBP declined by about 10 mmHg and the prevalence of hypertension declined from 46% to 25% in men and from 30% to 14% in women. The proportion of individuals with hypertension who were treated increased sixfold (from 7% to 42%) between 1979 and 2015, and the proportion of adults with hypertension that were successfully controlled also increased sixfold from 10% to 60% between 1979 and 2015.
Conclusions: Although this study demonstrated a halving in the age-specific prevalence of hypertension in men and women and a sixfold increase in treatment and control of hypertension, the burden of hypertension remains high among older people in Norway
Comparing associations of handgrip strength and chair stand performance with all-cause mortalityâimplications for defining probable sarcopenia: the Tromsø Study 2015â2020
Background Widely adopted criteria suggest using either low handgrip strength or poor chair stand performance to identify probable sarcopenia. However, there are limited direct comparisons of these measures in relation to important clinical endpoints. We aimed to compare associations between these two measures of probable sarcopenia and all-cause mortality. Methods Analyses included 7838 community-dwelling participants (55% women) aged 40â84 years from the seventh survey of the Tromsø Study (2015â2016), with handgrip strength assessed using a Jamarâ+âDigital Dynamometer and a five-repetition chair stand test (5-CST) also undertaken. We generated sex-specific T-scores and categorised these as ânot lowâ, âlowâ, and âvery lowâ handgrip strength or 5-CST performance. Cox Proportional Hazard regression models were used to investigate associations between these two categorised performance scores and time to death (up to November 2020 ascertained from the Norwegian Cause of Death registry), adjusted for potential confounders including lifestyle factors and specific diseases. Results A total of 233 deaths occurred (median follow-up 4.7 years) with 1- and 5-year mortality rates at 3.1 (95% confidence interval [CI] 2.1, 4.6) and 6.3 (95% CI 5.5, 7.2) per 1000 person-years, respectively. There was poor agreement between the handgrip strength and 5-CST categories for men (Cohenâs kappa [Îş]â=â0.19) or women (Îşâ=â0.20). Fully adjusted models including handgrip strength and 5-CST performance mutually adjusted for each other, showed higher mortality rates among participants with low (hazard ratio [HR] 1.22, 95% CI 0.87, 1.71) and very low (HR 1.68, 95% CI 1.02, 2.75) handgrip strength compared with the not low category. Similar associations, although stronger, were seen for low (HR 1.88, 95% CI 1.38, 2.56) and very low (HR 2.64, 95% CI 1.73, 4.03) 5-CST performance compared with the not low category. Conclusions We found poor agreement between T-score categories for handgrip strength and 5-CST performance and independent associations with mortality. Our findings suggest that these tests identify different people at risk when case-finding probable sarcopenia. As discussions on an international consensus for sarcopenia definitions proceed, testing both handgrip strength and chair stand performance should be recommended rather than viewing these as interchangeable assessments
The seventh survey of the Tromsø Study (Tromsø7) 2015â2016: study design, data collection, attendance, and prevalence of risk factors and disease in a multipurpose population-based health survey
Aims: The Tromsø Study is an ongoing population-based health study in Tromsø, Norway, initiated in 1974. The purpose
of the seventh survey (Tromsø7) 2015â2016 was to advance the population risk factor surveillance and to collect new
types of data. We present the study design, data collection, attendance, and prevalence of risk factors and disease. Methods:
All inhabitants in Tromsø municipality, Norway, aged 40 years and older (N=32,591) were invited to a health screening
including extensive questionnaires, face-to-face interviews, biological sampling (blood, urine, saliva, nasal/throat swabs,
faeces), measurements (anthropometry, blood pressure, pulse, pulse oximetry) and clinical examinations (pain sensitivity,
echocardiography, cognitive, physical, and lung function, accelerometer measurements, eye examinations, carotid ultrasound,
electrocardiography, dual-energy X-ray absorptiometry, and heart, lung and carotid auscultation). New research areas in
this round were dental and oral health examinations, collection of faecal samples for studies of normal bacterial flora and
antibiotic resistance, and 24-hour urine samples for examination of sodium and iodine intakes. Results: Attendance was
65% (N=21,083), and was higher in women, age group 50â79 years, previous attenders, and Norwegian-born individuals.
Cardiovascular risk factor levels and prevalence of chronic obstructive lung disease decreased since the last survey, while the
prevalence of obesity and diabetes increased. Conclusions: Attendance was stable from the sixth survey. Interaction
with participants might be key to maintain participation. Favourable trends in risk factors continue, except for
a continued increase in obesity. Both new data collection technology and traditional physical examinations will
be crucial for the impact of future population studies
Evaluating Complex Healthcare Systems: A Critique of Four Approaches
The purpose of this paper is to bring clarity to the emerging conceptual and methodological literature that focuses on understanding and evaluating complex or âwholeâ systems of healthcare. An international working group reviewed literature from interdisciplinary or interprofessional groups describing approaches to the evaluation of complex systems of healthcare. The following four key approaches were identified: a framework from the MRC (UK), whole systems research, whole medical systems research described by NCCAM (USA) and a model from NAFKAM (Norway). Main areas of congruence include acknowledgment of the inherent complexity of many healthcare interventions and the need to find new ways to evaluate these; the need to describe and understand the components of complex interventions in context (as they are actually practiced); the necessity of using mixed methods including randomized clinical trials (RCTs) (explanatory and pragmatic) and qualitative approaches; the perceived benefits of a multidisciplinary team approach to research; and the understanding that methodological developments in this field can be applied to both complementary and alternative medicine (CAM) as well as conventional therapies. In contrast, the approaches differ in the following ways: terminology used, the extent to which the approach attempts to be applicable to both CAM and conventional medical interventions; the prioritization of research questions (in order of what should be done first) especially with respect to how the âdefinitiveâ RCT fits into the process of assessing complex healthcare systems; and the need for a staged approach. There appears to be a growing international understanding of the need for a new perspective on assessing complex healthcare systems
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